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Objective
The authors hypothesize that an untargeted metabolomics study will identify novel mechanisms underlying smoking‐associated weight loss.
Methods
This study performed cross‐sectional analyses among 1,252 participants in the Bogalusa Heart Study and assessed 1,202 plasma metabolites for mediation effects on smoking‐BMI associations. Significant metabolites were tested for associations with...
Objective
This study aimed to examine the association of socioeconomic status with obesity.
Methods
A total of 39,262 twin individuals were included from the Chinese National Twin Registry (CNTR). Generalized estimating equation models for unmatched twin individual analyses and conditional logistic regression for the co‐twin matched design were used. Inference about Causation through Examination...
Objective
Modest weight loss (5%‐10%) is clinically meaningful in patients with overweight or obesity. However, greater weight loss may be required to achieve improvements in or remission of certain weight‐related complications. Therefore, this study reviewed the effect of large weight loss (≥10%). Most studies reporting large weight loss and relevant outcomes used bariatric surgery or lifestyle...
Objective
In this study, the effect of lomitapide, a microsomal triglyceride transfer protein inhibitor, on the cardiovascular function in obesity was investigated.
Methods
Eight‐week‐old C57BL/6 mice were fed with high‐fat diet for 12 weeks in the presence and absence of lomitapide. Lomitapide was administered by gavage (1 mg/kg/d) during the last 2 weeks of high‐fat feeding. Body weight, blood...
Objective
The aim of this study was to determine whether the hormone changes following weight loss are proportional to the degree of weight loss and to starting BMI.
Methods
A very low‐energy diet was used to achieve 15% weight loss. Fasting and postprandial gut hormones and leptin were measured during a meal test at baseline and at 5% (1%), 10% (2%), and 15% (2.5%) weight loss. Linear mixed‐effects...
Objective
This study evaluated whether the transition of a face‐to‐face behavioral intervention to videoconferencing‐based telehealth delivery during the COVID‐19 pandemic resulted in significantly smaller weight losses than those typically observed in gold‐standard, face‐to‐face programs.
Methods
Participants were 160 adults with obesity (mean [SD] age = 49.2 [11.9] years, BMI = 36.1 [4.2] kg/m...
Objective
Given the importance of body fat distribution in chronic disease development, feasible methods to assess body fat are essential. This study compared dual‐energy x‐ray absorptiometry (DXA) in measuring visceral and subcutaneous adipose tissue (VAT and SAT) with magnetic resonance imaging (MRI).
Methods
VAT and SAT were assessed using similar DXA and MRI protocols among 1,795 elderly participants...
Objective
The triad of obesity, a high‐protein diet from animal sources, and disturbed gut microbiota have been linked to poor clinical outcomes in patients with COVID‐19. In this report, the effect of oxidative stress resulting from the Na+/K+‐ATPase transporter signaling cascade is explored as a driver of this poor clinical outcome.
Methods
Protein–protein interactions with the SARS‐CoV‐2 proteome...
Objective
The aim of this study was to evaluate the effectiveness of the Children’s Food and Beverage Advertising Initiative (CFBAI) in reducing children’s exposure to ads for candy and sweetened beverages.
Methods
Survey data were used to determine the television programs that children watch and the time slots during which they watch television. Advertisement placement data were used to count...
Objective
The goal of this study was to determine whether the degree of weight loss after 6 months of a behavior‐based intervention is related to baseline connectivity within two functional networks (FNs) of interest, FN1 and FN2, in a group of older adults with obesity.
Methods
Baseline functional magnetic resonance imaging data were collected following an overnight fast in 71 older adults with...
Obesity‐focused health policies, including the landmark Treat and Reduce Obesity Act, have stalled at the federal level over the past decade. Congressional inaction on obesity reflects both misconceptions of obesity as a lifestyle choice and limited awareness for the burden obesity imposes on our health care system. Given these challenges, we argue that health professionals must bolster their efforts...
Objective
In this secondary analysis of the Rural Engagement in Primary Care for Optimizing Weight Reduction (RE‐POWER) randomized trial, the authors determined the effectiveness of weight‐loss interventions in people with diabetes compared with those without diabetes living in rural areas.
Methods
The RE‐POWER study was a randomized trial designed to determine the effectiveness of nonpharmacological...
Objective
The aim of this study was to test the hypothesis that ephedrine + caffeine (EC) reduces the fall in resting energy expenditure (REE) following bariatric surgery.
Methods
This 32‐week, randomized, double‐blinded, placebo‐controlled trial included 142 patients who underwent Roux‐en‐Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgery. Participants were randomized to either EC or placebo...
New appetite‐regulating antiobesity treatments such as semaglutide and agents under investigation such as tirzepatide show promise in achieving weight loss of 15% or more. Energy expenditure, fat oxidation, and lean mass preservation are important determinants of weight loss and weight‐loss maintenance beyond appetite regulation. This review discusses prior failures in clinical development of weight‐loss...
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